The film tells the story of three people for a year a son (Magimel) diagnosed with cancer, a mother (Deneuve) suffering from helplessness and a doctor (Cécile de France) to do her job One year and four seasons for these three characters to deal with the disease, to tame it, and to understand what it means to die while alive.
Desperate for companionship on a post apocalyptic Halloween night, the Last Girl on Earth gets more than she bargained for, when something far more sinister arrives on her doorstep.
A narcotics officer faces a personal crisis when his teenage daughter becomes addicted to drugs. After trying various approaches to help her, he leaves law enforcement to create a women's recovery center.